Changes in the prognosis of CADASIL over time: a 23-year study in 555 individuals
The clinical phenotype of CADASIL is improving. While this may be partly explained by reduced vascular risk factors such as smoking and the identification of milder cases, differences persisted after controlling for risk factors and mutation sites. These updated risk estimates should be used when counselling patients with CADASIL on prognosis.
Authors
- Hugh S. Markus (ORCID: https://orcid.org/0000-0002-9794-5996)
- Fatemeh Koohi (ORCID: https://orcid.org/0000-0003-1326-8594)
- Amy A. Jolly (ORCID: https://orcid.org/0000-0003-2669-4998)
- Nontapat Sukhonpanich (ORCID: https://orcid.org/0009-0002-4471-4913)
Institutions
- Siriraj Hospital (TH)
- University of Cambridge (GB)
- Mahidol University (TH)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1136/jnnp-2024-334823
- Citations
- 8
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.95
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- University of Cambridge
- Cambridge University Hospitals