Mechanisms of Type 2 Diabetes Remission After Bariatric and Metabolic Surgery

Obesity and diabetes mellitus are two closely related disorders that increase the incidence of morbidity and mortality. A direct relationship has been established between weight loss and improvement of metabolic disorders such as hypertension, diabetes mellitus, lipid metabolism, sleep apnea, and comorbidities - nonalcoholic fatty liver disease. polycystic ovary syndrome, infertility. Bariatric surgery is the most effective treatment for obesity. Remission of diabetes results from improved β-cell function, increased insulin sensitivity, and changes in the gut and adipose tissue. Compared to intensive medical treatment and lifestyle intervention, metabolic surgery has shown superiority in improving glycemia, reducing medications, and reducing cardiovascular risk factors, implying long-term benefits. on cardiovascular morbidity and mortality.