Tristetraprolin-mediated mRNA destabilization regulates basophil inflammatory responses
TTP is a key regulator of basophil activation, controlling the production of inflammatory mediators through mRNA destabilization. Our in vivo findings demonstrate that the absence of TTP in basophils significantly aggravates allergic skin inflammation, highlighting its potential as a therapeutic target for allergic diseases.
Authors
- Yutaro Uchida (ORCID: https://orcid.org/0000-0002-2790-6879)
- Perry J. Blackshear (ORCID: https://orcid.org/0000-0002-9561-8529)
- Kazufusa Takahashi (ORCID: https://orcid.org/0009-0007-9407-7111)
- Kensuke Miyake (ORCID: https://orcid.org/0000-0003-1149-3755)
- Tomoki Chiba (ORCID: https://orcid.org/0000-0001-5472-9030)
- Hajime Karasuyama (ORCID: https://orcid.org/0000-0003-0689-0836)
- Junya Ito (ORCID: https://orcid.org/0009-0000-0239-3969)
- Hiroshi Asahara
Institutions
- Tokyo Institute of Technology (JP)
- National Institute of Environmental Health Sciences (US)
- Institute of Medicinal Molecular Design (JP)
- Systems Biology Institute (JP)
- Japan Research Institute (JP)
- Institute of Science Tokyo (JP)
Publication Details
- Journal
- Allergology International
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1016/j.alit.2024.10.005
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00