Selective targeting of phosphodiesterases to develop potent antiparasitic drugs
Regulation of intracellular cyclic nucleotides to avoid homeostatic imbalances is achieved through catabolic activity of phosphodiesterases (PDEs). Recently, Ajiboye et al. reported validation of Cryptosporidium PDE1 (CpPDE1) as a viable drug target and identified optimized pyrazolopyrimidines with selective activity against CpPDE1 over human PDEs and with potent anticryptosporidial efficacy.
Authors
- William H. Witola (ORCID: https://orcid.org/0000-0002-2308-0539)
- Md. Mukthar Mia (ORCID: https://orcid.org/0000-0002-7495-0178)
- Shahbaz M. Khan (ORCID: https://orcid.org/0000-0002-6239-9446)
Institutions
- Johns Hopkins University (US)
- University of Illinois Urbana-Champaign (US)
- Urbana University (US)
Publication Details
- Journal
- Trends in Parasitology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1016/j.pt.2024.11.001
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00