Cyclometalated <i>N</i>-Difluoromethylbenzimidazolylidene Platinum(II) Complexes with Built-in Secondary Coordination Spheres: Photophysical Properties and Bioimaging
Bidentate Pt(II) complexes with cyclometalated <i>N</i>-heteroarene or <i>N</i>-heterocyclic carbene (NHC) ligands have been extensively studied as phosphorescent emitters over the past two decades. Herein, we introduce a difluoromethyl group (CF<sub>2</sub>H) into the wingtip of NHCs, where CF<sub>2</sub>H acts as a lipophilic hydrogen bond (HB) donor. Their cyclometalated Pt(II) complexes show excellent PLQYs (up to 93%) and phosphorescence lifetimes mainly due to the rigid structure with hydrogen bonding between the CF<sub>2</sub>H group and the adjacent O atom at the β-diketonate ligand. Bioimaging studies demonstrate high cellular uptake efficiency and deep tumor penetration capability of complex <b>7</b> in HeLa cells and multicellular tumor spheroids, highlighting their potential as bioimaging probes.
Authors
- Xiaoyu Yan (ORCID: https://orcid.org/0000-0003-3973-3669)
- Bingran Yu (ORCID: https://orcid.org/0000-0003-4912-5632)
- Rong-Yao Gao
- Xingyu Xu (ORCID: https://orcid.org/0000-0002-7015-9717)
- Jingli Zhang (ORCID: https://orcid.org/0000-0002-9590-0153)
- Zengyu Zhang (ORCID: https://orcid.org/0000-0001-5333-9911)
- Mengrui Su
Institutions
- Xinzhou Teachers University (CN)
- Beijing University of Chemical Technology (CN)
- Renmin University of China (CN)
Publication Details
- Journal
- Inorganic Chemistry
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1021/acs.inorgchem.4c03713
- Citations
- 4
- Primary Topic
- Organic Light-Emitting Diodes Research
- Type
- article
- Field-Weighted Citation Impact
- 0.83
Funders
- National Natural Science Foundation of China
- Renmin University of China
- Fundamental Research Funds for the Central Universities