Activation of Hippocampal Neuronal NADPH Oxidase NOX2 Promotes Depressive-Like Behaviour and Cognition Deficits in Chronic Restraint Stress Mouse Model
Our study indicated that neuronal NOX2 may be a critical mediator of depression-like behaviours and spatial cognitive deficits in mice subjected to CRS. Blockade of NOX2 signalling may be a promising therapeutic strategy for depression.
Authors
- Fangfang Qi
- Z. B. Li (ORCID: https://orcid.org/0000-0003-0208-9523)
- Junhua Yang (ORCID: https://orcid.org/0000-0001-8037-9644)
- Zejie Zuo (ORCID: https://orcid.org/0000-0002-4035-8731)
- Hongyang Zhang (ORCID: https://orcid.org/0000-0001-9447-8731)
- Zhibin Yao (ORCID: https://orcid.org/0000-0003-1613-9157)
- Haojie Hu (ORCID: https://orcid.org/0009-0003-4288-8001)
Institutions
- Florida State University (US)
- Sun Yat-sen University (CN)
- Guangdong Pharmaceutical University (CN)
- Mayo Clinic in Arizona (US)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- New York University (US)
Publication Details
- Journal
- Pharmacopsychiatry
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1055/a-2429-4023
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25