Cerebral Oxygen Metabolic Stress in Children and Adults With Large Vessel Vasculopathy Due to Sickle Cell Disease
Beyond greater infarct burden, LVV was associated with hemispheric atrophy and white matter microstructural injury. As an indicator of active hypoxia, elevated nOEF likely represents a compensatory response to flow-limiting stenosis in hemispheres with LVV. The study is limited by a small number of patients with severe stenosis. Future studies are needed to evaluate the potential of tissue-based CBF and nOEF in assessing stroke risk and guide timely treatment of vasculopathy in SCD.
Authors
- Melanie E. Fields (ORCID: https://orcid.org/0000-0001-6223-4468)
- Andria L. Ford (ORCID: https://orcid.org/0000-0003-0605-8943)
- Jin‐Moo Lee (ORCID: https://orcid.org/0000-0002-3979-0906)
- Yasheng Chen (ORCID: https://orcid.org/0000-0002-1133-452X)
- Monica L. Hulbert (ORCID: https://orcid.org/0000-0001-8933-0046)
- Allison A. King (ORCID: https://orcid.org/0000-0002-1951-6176)
- Martin Reis
- Karen Steger-May (ORCID: https://orcid.org/0000-0002-3335-9111)
- Chunwei Ying (ORCID: https://orcid.org/0000-0003-1060-3289)
- Hongyu An (ORCID: https://orcid.org/0000-0001-6459-2269)
- Amy Mirro (ORCID: https://orcid.org/0000-0001-5501-7342)
- J. B. Lewis (ORCID: https://orcid.org/0000-0001-5758-245X)
- Kristin P. Guilliams (ORCID: https://orcid.org/0000-0002-5518-3778)
- Slim Fellah (ORCID: https://orcid.org/0000-0001-6179-6389)
- Yan Wang (ORCID: https://orcid.org/0000-0002-3750-0311)
- Rachel Cohen
Institutions
- Mahindra and Mahindra Limited (India) (IN)
Publication Details
- Journal
- Neurology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1212/wnl.0000000000210032
- Primary Topic
- Neurological Complications and Syndromes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- bluebird bio
- Novo Nordisk
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences