Multi-omics-driven discovery of invasive patterns and treatment strategies in CA19-9 positive intrahepatic cholangiocarcinoma
This study systematically elucidated the clinical, genomic, transcriptomic, and immune features of CA19-9 positive ICC. It reveals glycolysis-associated cellular communities and their cancer-promoting mechanisms, enhancing our understanding of ICC and laying the groundwork for individualized therapeutic strategies.
Authors
- Jiye Zhu (ORCID: https://orcid.org/0000-0003-0456-7584)
- Jialing Hao (ORCID: https://orcid.org/0000-0001-9114-3231)
- Delin Ma (ORCID: https://orcid.org/0000-0001-6886-9886)
- Wenzai Shi
- Hengkang Liu (ORCID: https://orcid.org/0000-0002-4103-4704)
- Zhuomiaoyu Chen (ORCID: https://orcid.org/0009-0001-2800-0884)
- Pengcheng Wei (ORCID: https://orcid.org/0000-0003-0002-9439)
- Zhigao Yuan
- Zuyin Li
- Jie Gao (ORCID: https://orcid.org/0000-0002-6523-4882)
- Li Zhao (ORCID: https://orcid.org/0000-0003-0512-2835)
- Qian Cheng (ORCID: https://orcid.org/0000-0002-4750-7859)
- Yingming Chu (ORCID: https://orcid.org/0000-0003-2074-5651)
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
- Peking University First Hospital (CN)
- Peking University International Hospital (CN)
- Aviation General Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12967-024-05854-9
- Citations
- 15
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.59
Funders
- Capital Health Research and Development of Special Fund