Identification and validation of biomarkers related to mitochondria during ex vivo lung perfusion for lung transplants based on machine learning algorithm
Imbalance in mitochondrial homeostasis is a shared pathological process during EVLP and I/R-induced lung injury. The identified hub mitochondrial-related genes (MTERF1, ACACA, COX15, OSGEPL1, and COQ9) suggest promising therapeutic targets for lung injury during LTx. The downregulation of these genes indicates a significant disruption in mitochondrial function. This study provides potential mitochondrial-related therapeutic targets for I/R-induced lung injury and for donor lung repair during EVLP procedure in LTx.
Authors
- Zhao Yang (ORCID: https://orcid.org/0000-0002-7475-1080)
- Zhi-Chang Yang
- Junnan Wu (ORCID: https://orcid.org/0000-0002-0624-2057)
- Weihua Lu (ORCID: https://orcid.org/0000-0003-3041-2041)
- Hao‐Xiang Yuan
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Yang Yang (ORCID: https://orcid.org/0000-0002-2630-6062)
- Tong Zheng (ORCID: https://orcid.org/0009-0005-1488-2846)
- Kaijun Huang (ORCID: https://orcid.org/0000-0002-5172-3212)
- Zhen-Yang Geng (ORCID: https://orcid.org/0009-0004-0851-7060)
Institutions
- Guangdong General Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Anyang Tumor Hospital (CN)
Publication Details
- Journal
- Gene
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1016/j.gene.2024.149097
- Citations
- 7
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.01