Increased COX6A2 Promotes Pancreatic β-Cell Apoptosis and Is Suppressed in Diabetic GK Rats After Roux-en-Y Gastric Bypass
Cytochrome c oxidase subunit 6A2 (COX6A2) expression is increased in diabetic islets. Increased COX6A2 promotes β-cell apoptosis via modulation of cyclophilin D-mediated cytochrome c release from mitochondria to the cytoplasm. Carbohydrate-responsive element-binding protein epigenetically regulates COX6A2 expression in β-cells. Roux-en-Y gastric bypass reduces COX6A2 expression by regulating the glucagon-like peptide 1/cAMP-dependent protein kinase/carbohydrate-responsive element-binding protein signaling pathway.
Authors
- Xing‐sheng Shu (ORCID: https://orcid.org/0000-0003-2461-4253)
- Yifan Tu (ORCID: https://orcid.org/0000-0002-2728-6753)
- Xiangchen Kong (ORCID: https://orcid.org/0000-0001-5149-1987)
- Ying Ying (ORCID: https://orcid.org/0000-0002-2926-6051)
- Bingfeng Li (ORCID: https://orcid.org/0000-0002-6424-9193)
- Xiaosong Ma (ORCID: https://orcid.org/0000-0001-5809-6007)
- Dan Yan (ORCID: https://orcid.org/0000-0002-8428-3700)
- Lianqi Shao
- Simian Lv
- Yingqi Zhang
Institutions
- Jiamusi University (CN)
- Chinese University of Hong Kong (HK)
- Shenzhen University (CN)
- Shenzhen University Health Science Center (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Diabetes
- Published
- 2024-11-15
- DOI
- https://doi.org/10.2337/db24-0301
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.15