Integrated proteomics and scRNA-seq analyses of ovarian cancer reveal molecular subtype-associated cell landscapes and immunotherapy targets
Our study refines the current immune subtype for EOC, highlighting CD40 agonists as promising therapies for C2 subtype patients and targeting TYMP for non-immune patients.
Authors
- Jun Qin (ORCID: https://orcid.org/0000-0003-3769-3720)
- Wenqing Yang (ORCID: https://orcid.org/0000-0002-4721-6197)
- Lun‐Quan Sun (ORCID: https://orcid.org/0000-0002-0558-5250)
- Fang Zhu (ORCID: https://orcid.org/0000-0003-3990-2346)
- Nairen Zheng (ORCID: https://orcid.org/0000-0002-3952-1570)
- Rong Tan (ORCID: https://orcid.org/0000-0002-3629-8668)
- Ming Wen (ORCID: https://orcid.org/0000-0001-8081-444X)
- Dongdong Zhan (ORCID: https://orcid.org/0000-0002-0704-8782)
- Yi Wang (ORCID: https://orcid.org/0000-0002-0192-3195)
- Meng Wang (ORCID: https://orcid.org/0000-0002-3094-7735)
- Mingwei Liu (ORCID: https://orcid.org/0000-0002-7498-8600)
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Bin Xie (ORCID: https://orcid.org/0000-0003-2034-0160)
- Qiongqiong He (ORCID: https://orcid.org/0000-0003-3564-3893)
- Xiaodan Chen (ORCID: https://orcid.org/0009-0002-8965-140X)
- Kai Yuan
- Siyu Yang (ORCID: https://orcid.org/0009-0006-0455-0490)
Institutions
- Central South University (CN)
- Hunan University (CN)
- Fudan University (CN)
- Key Laboratory of Guangdong Province (CN)
- National Clinical Research (US)
- Beijing Proteome Research Center (CN)
- Dian Diagnostics (China) (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1038/s41416-024-02894-2
- Citations
- 6
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Central South University
- Xiangya Hospital, Central South University