Gene Polymorphisms Play an Important Role in the Drug Interaction Between Posaconazole and Tacrolimus in Renal Transplant Patients
In renal transplant patients, considerable interindividual variability was observed in the drug interactions between POSA and TAC. The genotypes of CYP3A5*3 and ABCB1 3435 and the plasma level of POSA had strong impact on the interaction between POSA and TAC.
Authors
- Nan Hu (ORCID: https://orcid.org/0000-0002-7505-5001)
- Qing Qian (ORCID: https://orcid.org/0000-0001-6019-9187)
- Hui Xue (ORCID: https://orcid.org/0000-0002-4561-5530)
- Xuping Yang (ORCID: https://orcid.org/0000-0002-4617-9232)
- Mengmeng Guan
- Di Zhao (ORCID: https://orcid.org/0000-0002-8630-8908)
- Bin Gu (ORCID: https://orcid.org/0000-0002-5594-2463)
- J. Jiang
Institutions
- China Pharmaceutical University (CN)
- Soochow University (CN)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1097/ftd.0000000000001272
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00