Lacosamide Pharmacokinetics and Retention in Japanese Patients With Epilepsy: A Retrospective Study on the Influence of Age, Comedications, and Cytochrome P450 2C19 Polymorphism
Age and the concomitant use of enzyme-inducing ASMs influence LCM pharmacokinetics. In addition, patients with the PM phenotype have a high LCM CD ratio, which may decrease treatment retention. Therapeutic drug monitoring for LCM is a clinically useful method for evaluating pharmacokinetics in individual patients and optimizing the dose of LCM.
Authors
- Takuji Nishida (ORCID: https://orcid.org/0000-0001-5391-4656)
- Yuka Shiratani
- Katsumi Imai (ORCID: https://orcid.org/0000-0001-8438-9284)
- Yoshiaki Yamamoto (ORCID: https://orcid.org/0000-0002-8452-448X)
- Yoshiyuki Kagawa (ORCID: https://orcid.org/0000-0002-4902-1625)
- Naotaka Usui (ORCID: https://orcid.org/0000-0002-9736-7460)
- Yukitoshi Takahashi (ORCID: https://orcid.org/0000-0002-1922-8967)
Institutions
- University of Shizuoka (JP)
- National Epilepsy Center (JP)
- Shizuoka General Hospital (JP)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1097/ftd.0000000000001278
- Citations
- 3
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.33