Parvovirus infection in adults: a series of case reports in post-pandemic period

Parvovirus infection in immunocompetent patients usually has a mild or asymptomatic course, but some cases may be characterized by a complicated course that requires hospitalization. The aim of our work was the characterization of clinical course of parvovirus infection in immunocompetent patients who required hospitalization. The article discussed three clinical cases of infection caused by human parvovirus B19. Our patients had a pronounced general intoxication syndrome with fever, severe anemia, hepatitis with moderate biochemical activity, and splenomegaly in the first clinical case; erythema multiforme, severe thrombocytopenia and leukopenia in the second clinical case; pericarditis with purple rash in the third clinical case. Patients with immunosuppression could have chronic anemia, pancytopenia, myocarditis, pneumonitis, hepatitis, meningitis, and encephalitis in a course of parvovirus infection. HIV infection was ruled out for all our patients; however, these patients were routinely recommended to undergo additional examinations in order to rule out other possible causes of immunosuppression. Clinical vigilance regarding parvovirus infection is currently relevant, and complex specific diagnostics (serological, immunoblotting and Polymerase Chain Reaction assays) are available and cоuld be used in diagnostic cases to determine the tactics of further examination and treatment. Keywords: parvovirus B19, anemia, thrombocytopenia, leukopenia, hepatitis, pericarditis.