Proof of concept for a superior therapeutic index of corticosterone compared with hydrocortisone in patients with congenital adrenal hyperplasia
Corticosterone acutely controls biochemical markers of androgen excess similarly to hydrocortisone but without inducing markers of glucocorticoid "toxicity" in CAH. These data demonstrate proof of concept that corticosterone may be a safer glucocorticoid replacement than current medications, although further research is required to assess the longer-term effects of corticosterone replacement.
Authors
- Luke D Boyle (ORCID: https://orcid.org/0000-0003-4739-9170)
- Joanna Simpson (ORCID: https://orcid.org/0000-0002-0939-8487)
- Brian R. Walker (ORCID: https://orcid.org/0000-0002-2416-1648)
- Ruth Andrew (ORCID: https://orcid.org/0000-0002-6916-2994)
- Roland H. Stimson (ORCID: https://orcid.org/0000-0002-9002-6188)
- Mark Nixon (ORCID: https://orcid.org/0000-0001-5437-3724)
- Alison L. Rutter (ORCID: https://orcid.org/0009-0007-0759-7961)
- Natalie Z M Homer (ORCID: https://orcid.org/0000-0002-9262-2098)
- Catriona Kyle (ORCID: https://orcid.org/0000-0002-2091-0736)
- Alexandra Kelman
- Ellen Marie Freel
- Lynne Ramage
Institutions
- Clinical Research Institute (US)
- Queen Elizabeth University Hospital (GB)
- The Queen's Medical Research Institute (GB)
- University of Glasgow (GB)
- Newcastle University (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1093/ejendo/lvae144
- Citations
- 1
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.36
Funders
- Wellcome Trust
- British Heart Foundation
- Chief Scientist Office