Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study
Maternal education was strongly correlated with adolescent brain morphology, cognitive performances, and mental health. However, the molecular basis for the effects of maternal education on the structural neurodevelopment remains unknown. Here, we conducted gene-environment-wide interaction study using the Adolescent Brain Cognitive Development cohort. Seven genomic loci with significant gene-environment interactions (G×E) on regional gray matter volumes were identified, with enriched biological functions related to metabolic process, inflammatory process, and synaptic plasticity. Additionally, genetic overlapping results with behavioral and disease-related phenotypes indicated shared biological mechanism between maternal education modified neurodevelopment and related behavioral traits. Finally, by decomposing the multidimensional components of maternal education, we found that socioeconomic status, rather than family environment, played a more important role in modifying the genetic effects on neurodevelopment. In summary, our study provided analytical evidence for G×E effects regarding adolescent neurodevelopment and explored potential biological mechanisms as well as social mechanisms through which maternal education could modify the genetic effects on regional brain development.
Authors
- Andreas Heinz (ORCID: https://orcid.org/0000-0001-5405-9065)
- Sylvane Desrivières (ORCID: https://orcid.org/0000-0002-9120-7060)
- Hugh P Garavan (ORCID: https://orcid.org/0000-0002-8939-1014)
- Rüdiger Brühl (ORCID: https://orcid.org/0000-0003-0111-5996)
- Runye Shi (ORCID: https://orcid.org/0000-0002-1388-2079)
- Tobias Banaschewski (ORCID: https://orcid.org/0000-0003-4595-1144)
- Xiao Chang (ORCID: https://orcid.org/0000-0002-8076-8110)
- Sarah Hohmann (ORCID: https://orcid.org/0000-0002-5175-6698)
- Marie‐Laure Paillère Martinot (ORCID: https://orcid.org/0000-0002-0452-2450)
- Arun L.W. Bokde (ORCID: https://orcid.org/0000-0003-0114-4914)
- Nathalie Holz (ORCID: https://orcid.org/0000-0002-6225-9267)
- Herta Flor (ORCID: https://orcid.org/0000-0003-4809-5398)
- Antoine Grigis (ORCID: https://orcid.org/0000-0001-7984-3710)
- Robert Whelan (ORCID: https://orcid.org/0000-0002-2790-7281)
- Henrik Walter (ORCID: https://orcid.org/0000-0002-9403-6121)
- Luise Poustka (ORCID: https://orcid.org/0000-0002-7738-4394)
- Xiaolei Lin (ORCID: https://orcid.org/0000-0003-2463-1272)
- Michael N. Smolka (ORCID: https://orcid.org/0000-0001-5398-5569)
- Dimitri Papadopoulos Orfanos (ORCID: https://orcid.org/0000-0002-1242-8990)
- Frauke Nees (ORCID: https://orcid.org/0000-0002-7796-8234)
- Gareth J. Barker (ORCID: https://orcid.org/0000-0002-5214-7421)
- Jianfeng Feng (ORCID: https://orcid.org/0000-0002-9328-5732)
- Penny Anne Gowland (ORCID: https://orcid.org/0000-0002-4900-4817)
- Eric Artiges A (ORCID: https://orcid.org/0000-0003-4461-7646)
- Günter Schumann (ORCID: https://orcid.org/0000-0002-7740-6469)
- Jean-Luc Martinot
- Nilakshi Vaidya (ORCID: https://orcid.org/0000-0002-4600-7158)
Institutions
- University of Vermont (US)
- Physikalisch-Technische Bundesanstalt (DE)
- Centre National de la Recherche Scientifique (FR)
- University of Nottingham (GB)
- Inserm (FR)
- Universität Hamburg (DE)
- University of Mannheim (DE)
- King's College London (GB)
- Trinity College Dublin (IE)
- Heidelberg University (DE)
- Fudan University (CN)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- University Hospital Heidelberg (DE)
- Shanghai Innovative Research Center of Traditional Chinese Medicine (CN)
- Christian-Albrechts-Universität zu Kiel (DE)
- Humboldt-Universität zu Berlin (DE)
- University of Warwick (GB)
- Sorbonne Université (FR)
- Shanghai Institute for Science of Science (CN)
- Assistance Publique – Hôpitaux de Paris (FR)
- Central Institute of Mental Health (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Pitié-Salpêtrière Hospital (FR)
- CEA Paris-Saclay (FR)
- Laboratoire de Biologie et Pharmacologie Appliquée (FR)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- University of Göttingen (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Science Advances
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1126/sciadv.adp3751
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Medical Research Council