Stem cell factor restrains endoplasmic reticulum stress-associated apoptosis through c-Kit receptor activation of JAK2/STAT3 axis in hippocampal neuronal cells
We found that SCF inhibits L-Glu-induced ER stress-associated apoptosis via JAK2/STAT3 axis in HT22 hippocampal neuronal cells, as well as in primary hippocampal neurons from APP/PS1 mice, which provides valuable insights into the molecular mechanisms underlying the pathogenesis of AD and explores novel therapeutic targets for both sporadic and familial AD.
Authors
- Yang Shuyan
- Hongyan Tian
- Haiying Shen (ORCID: https://orcid.org/0009-0001-6320-6271)
- Guifang Zhao (ORCID: https://orcid.org/0000-0003-4600-5686)
- Wei‐Yao Wang (ORCID: https://orcid.org/0000-0002-6551-1720)
- Junjie Nie (ORCID: https://orcid.org/0000-0002-4384-2289)
- Zhonghua Zheng (ORCID: https://orcid.org/0000-0002-0642-650X)
- Guangqing Li
- Yuji Jin (ORCID: https://orcid.org/0009-0006-0133-627X)
- Jun Zhang (ORCID: https://orcid.org/0000-0002-1826-6099)
- Jie Sun
- Hong Zhang (ORCID: https://orcid.org/0000-0002-1272-428X)
- Dongfang Zhang (ORCID: https://orcid.org/0000-0003-0929-7958)
- Xiaofeng Luo
- Da Xu (ORCID: https://orcid.org/0000-0003-3565-7128)
Institutions
- People 's Hospital of Jilin Province (CN)
- Jilin Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1371/journal.pone.0310872
- Citations
- 7
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.28
Funders
- People's Government of Jilin Province
- Education Department of Jilin Province