Deletion of <i>Fgfr2</i> in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

Our results substantiated the crucial role of Fgfr2 in homeostasis of the MG ductal epithelium. Deletion of Fgfr2 affects the MG ductal basal progenitors by impacting the differentiation of ductal meibocytes and the maintenance of acinar meibocytes, which are likely the underlying pathogenesis of obstructive MGD.

Authors

Andrew Huang (ORCID: https://orcid.org/0000-0003-1939-9149)
Lixing W. Reneker (ORCID: https://orcid.org/0000-0002-5622-1326)
Haotian Lin (ORCID: https://orcid.org/0000-0003-4672-9721)
Xiaowei Yang (ORCID: https://orcid.org/0000-0002-6800-7052)
Xingwu Zhong

Institutions

Sun Yat-sen University (CN)
Washington University in St. Louis (US)
Hainan Eye Hospital (CN)
University of Missouri (US)

Publication Details

Journal: Investigative Ophthalmology & Visual Science
Published: 2024-11-15
DOI: https://doi.org/10.1167/iovs.65.13.36
Citations: 1
Primary Topic: Ocular Surface and Contact Lens
Type: article
Field-Weighted Citation Impact: 0.54

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article

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

Andrew Huang, Lixing W. Reneker, Haotian Lin, Xiaowei Yang et al.

Nov 15, 2024

1 citations

Investigative Ophthalmology & Visual Science

Ocular Surface and Contact Lens

0.54

article

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

Andrew Huang, Lixing W. Reneker, Haotian Lin, Xiaowei Yang, Xingwu Zhong

November 15, 2024article en

1 citations

Abstract

Our results substantiated the crucial role of Fgfr2 in homeostasis of the MG ductal epithelium. Deletion of Fgfr2 affects the MG ductal basal progenitors by impacting the differentiation of ductal meibocytes and the maintenance of acinar meibocytes, which are likely the underlying pathogenesis of obstructive MGD.

Investigative Ophthalmology & Visual ScienceVol. 65(13)

Sun Yat-sen University (CN), Washington University in St. Louis (US), Hainan Eye Hospital (CN), University of Missouri (US)

Zero hunger

Openalex Percentile: Top 27%

Ocular Surface and Contact Lens

0.54

DOI Open Access PDF OpenAlex

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Deletion of <i>Fgfr2</i> in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction — Andrew Huang, Lixing W. Reneker, et al. · Investigative Ophthalmology & Visual Science (2024) | TGRS Research Map | TGRS