Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts
LOXL3 is crucial in GO pathogenesis. LOXL3 inhibition reduced inflammatory cytokine production, fibrotic protein expression, and fibroblast differentiation into adipocytes. This study highlights LOXL3 as a potential therapeutic target for GO.
Authors
- JaeSang Ko (ORCID: https://orcid.org/0000-0002-3011-7213)
- Seung Hyun Park (ORCID: https://orcid.org/0000-0002-6230-8321)
- Jin Sook Yoon (ORCID: https://orcid.org/0000-0002-8751-9467)
- Hyun‐Young Park (ORCID: https://orcid.org/0000-0002-6698-7368)
- Soo Hyun Choi (ORCID: https://orcid.org/0000-0003-1421-5283)
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1167/iovs.65.13.33
- Citations
- 5
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Research Foundation
- Yonsei University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Yonsei University College of Medicine