Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost
Travoprost treatment appears to soften corneal tissue, decrease tissue thickness, and reduce the density of stromal collagen fibers by increasing the interfibrillar spacing. These changes were partially reversed after treatment cessation. Travoprost could further inhibit corneal growth, so its use in childhood and adolescence should be carefully considered. Additionally, the effect of travoprost in reducing corneal stiffness may lead to underestimations of intraocular pressure (IOP) measurement and hence overestimations in the effect of treatment in lowering IOP.
Authors
- Ahmed Elsheikh (ORCID: https://orcid.org/0000-0001-7456-1749)
- Lingqiao Li (ORCID: https://orcid.org/0000-0001-9402-0421)
- Yiwen Fan (ORCID: https://orcid.org/0000-0001-8461-5130)
- Er-Wei Zhang (ORCID: https://orcid.org/0000-0002-9823-1151)
- Fangjun Bao (ORCID: https://orcid.org/0000-0001-9881-6267)
- Junjie Wang (ORCID: https://orcid.org/0000-0003-4708-9447)
- ShiHao Chen
- Yi Jin (ORCID: https://orcid.org/0000-0001-9704-973X)
- Chong Wang (ORCID: https://orcid.org/0000-0003-0022-0217)
- Han Bao (ORCID: https://orcid.org/0009-0009-7499-4136)
- Peng Yang (ORCID: https://orcid.org/0000-0003-1821-080X)
- XiaoBo Zheng
- Yuxin Hong
Institutions
- Moorfields Eye Hospital NHS Foundation Trust (GB)
- University of Liverpool (GB)
- Wenzhou Medical University (CN)
- National Institute for Health and Care Research (GB)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- University College London (GB)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1167/iovs.65.13.35
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province