Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia
In this secondary analysis of 4 randomized clinical trials, a high incidence of acute hyponatremia was observed in response to MDMA, which may be mitigated by fluid restriction. Hyponatremia was associated with acute oxytocin but not copeptin release. This challenges the current hypothesis of direct vasopressin release and rather indicates that oxytocin mimics the effect of vasopressin in the kidneys due to structural homology.
Authors
- Patrick Vizeli (ORCID: https://orcid.org/0000-0002-5954-4446)
- Friederike Holze (ORCID: https://orcid.org/0000-0003-3143-1519)
- Cihan Atila (ORCID: https://orcid.org/0000-0002-5442-7304)
- Isabelle Straumann (ORCID: https://orcid.org/0009-0008-2952-586X)
- Matthias E. Liechti (ORCID: https://orcid.org/0000-0002-1765-9659)
- Mirjam Christ‐Crain (ORCID: https://orcid.org/0000-0002-6336-0965)
- Sophie Monnerat (ORCID: https://orcid.org/0000-0002-0179-7889)
- Julia Beck (ORCID: https://orcid.org/0009-0007-8556-1075)
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.45278
- Citations
- 12
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 7.72