Biofilm: the invisible fortress of bacteria

Introduction: Biofilm is an organized and multidimensional association of biological agents that are located within an extracellular matrix composed of polysaccharides (polymeric), as well as proteins, mineral salts and DNA. Together with cellular remains that represent 10 or 20% of its compositionObjective: characterize antimicrobial resistance from the point of view of the BiofilmMethod: A bibliographic research was developed. Scielo, SCOPUS, and PubMed databases were used using the search terms and their English equivalents. After reviewing the title, summary and application of the inclusion criteria, we worked with 25 investigations. Development: the composition of Bioflim is described as a complex organization, which gradually gains structure. The Biofilm compound is typical of gram-negative bacteria as a result of its high resistance capacity. The regulatory process for the formation of compound Biofilms is based on complex networks of regulators. One of the compounds demonstrated in this system is quorum sensing or autoinduction. For a Biofilm compound to be considered harmful or associated with antimicrobial resistance, a series of characteristics must be present. Conclusions: Biofilm constitutes a biofilm made up of a heterogeneous group of molecules that give it similar characteristics, as well as peculiar ones for each of the bacteria. Its organization in structures, of greater complexity as the formation process progresses, allows it to respond to the adversities of the environment and a high capacity for antimicrobial resistance. Its composition and formation varies with each stage. For the most part, it is typical of gram-negative bacteria, which is the basis for their high capacity for resistance