Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation
In conclusion, we proposed a novel liver organoid construction method using rotating culture, by which the pluripotency of liver organoids so constructed is mediated by α<sub>4</sub>β<sub>6</sub>-integrin and YAP translocation. This work furthered the understanding in how the gravity vector orientation affects the construction of liver organoids and the related mechanotransductive pathways.
Authors
- Dongyuan Lü
- Lu Zheng (ORCID: https://orcid.org/0000-0002-3636-2631)
- Mian Long (ORCID: https://orcid.org/0000-0003-0819-6186)
- Sun Shujin
- Yi-Long Lung Cancer Wu (ORCID: https://orcid.org/0000-0002-3611-0258)
- Qing Luo
- Guanbin Song (ORCID: https://orcid.org/0000-0001-5217-0296)
- Shaoyu Zhong
Institutions
- Chongqing University (CN)
- Chinese Academy of Sciences (CN)
- Institute of Mechanics (BG)
- Institute of Mechanics (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12915-024-02062-1
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China