Characteristics of stromal components of proliferative, up to 10 mm leiomyomas - extracellular matrix, angiogenesis and fibrosis according to nodule size in perimenopausal patients

As it is known, the formation of leiomyoma is related to the violation of the synthesis of sex steroid hormones, genetic abnormalities and wound healing disorders. In the development of leiomyoma, the role of growth factors involved in the formation of the extracellular matrix is ​​discussed, these factors also play a role in impaired wound healing, which can then lead to tumorigenesis. Based on the fact that the risks of leiomyoma development exist in perimenopause, the aim of our research is to identify the characteristics of stromal components - extracellular matrix, angiogenesis and fibrosis in the proliferative, small-growing, up to 10mm leiomyomas in preparations stained with hematoxylin and eosin and Masson's trichrome according to the size of the nodes. Conclusion: 1. Proliferative, small-growing, active and remodeled (mainly deformed blood vessels, capillaries and arterioles) angiogenesis detected in nodules up to 10 mm gives us a reason to express an opinion about their mandatory role in the process of growth and development of leiomyoma during perimenopause. Premenopause is characterized by the process of active growth and development of nodes with activation of stromal components, an increase in the volume of the extracellular matrix and the characteristics of fibrosis, while in menopause and postmenopause the mentioned process is delayed and takes on a prolonged asymptomatic character.