Transcriptomic Profiling of Human Myocardium at Sudden Death to Define Vulnerable Substrate for Lethal Arrhythmias
RNA profiling of the myocardium at SCD identifies active fibrosis, undetectable by conventional clinical methods, in the presence of fixed scar and selected ion-channel dysregulation (more pronounced among female cases) as an acute vulnerable substrate for fatal arrhythmias. These findings may represent novel directions to identify patients at elevated near-term risk for SCD and critical pathways for intervention to reduce acute lethal arrhythmias.
Authors
- Kosuke Nakasuka (ORCID: https://orcid.org/0000-0002-8606-3613)
- Timothy J. Henrich (ORCID: https://orcid.org/0000-0002-6684-0622)
- Zian H. Tseng (ORCID: https://orcid.org/0000-0001-5996-4099)
- Arun Padmanabhan (ORCID: https://orcid.org/0000-0002-6806-3046)
- Hannah Sabeth Schwarzer-Sperber
- Roland Schwarzer (ORCID: https://orcid.org/0000-0002-7497-5180)
- David P. Maison (ORCID: https://orcid.org/0000-0003-3428-1931)
- Joseph C. Wu (ORCID: https://orcid.org/0000-0002-6068-8041)
- Jean Feng (ORCID: https://orcid.org/0000-0003-2041-3104)
- Ellen Moffatt (ORCID: https://orcid.org/0000-0002-3804-3116)
- Arianne Caudal (ORCID: https://orcid.org/0000-0001-9836-9436)
- Paul Pang (ORCID: https://orcid.org/0000-0001-7784-2300)
- Yu Liu (ORCID: https://orcid.org/0000-0001-7110-127X)
- Andrew J. Connolly (ORCID: https://orcid.org/0000-0002-0660-3270)
Institutions
- Office of Chief Medical Examiner (US)
- University of California, San Francisco (US)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- JACC. Clinical electrophysiology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1016/j.jacep.2024.08.013
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Frank A. Campini Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute