Cytomegalovirus infection of the fetal brain: intake of aspirin during pregnancy blunts neurodevelopmental pathogenesis in the offspring
Overall, our data indicate that, in the context of CMV infection of the fetal brain, maternal intake of ASA during pregnancy improved CMV-related neurodevelopmental alterations in the offspring, likely via both Cox-1 dependent and Cox-1 independent mechanisms, and provide proof-of-principle for the use of ASA against the detrimental outcomes of congenital CMV infections.
Authors
- Sarama Saha (ORCID: https://orcid.org/0000-0002-7838-9875)
- Thomas Stamminger (ORCID: https://orcid.org/0000-0001-9878-3119)
- Nail Burnashev (ORCID: https://orcid.org/0000-0002-0478-3810)
- Jean-Paul Paı̈s de Barros (ORCID: https://orcid.org/0000-0002-5124-2283)
- Emilie Pallesi‐Pocachard (ORCID: https://orcid.org/0009-0006-8430-9778)
- Pierre Szepetowski (ORCID: https://orcid.org/0000-0003-2060-8390)
- Carla Crespo-Quiles
- Louison Pineau
- Š. Bauer (ORCID: https://orcid.org/0000-0002-0667-3412)
- Hervé Luche (ORCID: https://orcid.org/0000-0003-4309-8338)
- Carlos Cardoso (ORCID: https://orcid.org/0000-0003-1914-9553)
- Emmanuelle Buhler
- Lucas Silvagnoli
- Sarah Tarhini
- Solène Villain
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Bourgogne (FR)
- Universität Ulm (DE)
- Johannes Gutenberg University Mainz (DE)
- Aix-Marseille Université (FR)
- Institut de Neurobiologie de la Méditerranée (FR)
- Issy Media (France) (FR)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12974-024-03276-4
- Citations
- 2
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Aix-Marseille Université