Exploring genetic associations between immune cells and hypertensive disorder of pregnancy using Mendelian randomization
This study showed that many immunophenotypes are implicated in HDP. Furthermore, the level of LOX-1 mediated the pathophysiology relationship between HLA DR on plasmacytoid dendritic cells and chronic hypertension prior to pregnancy.
Authors
- Jingting Liu (ORCID: https://orcid.org/0000-0001-8305-2495)
- Yijun Dong (ORCID: https://orcid.org/0000-0002-2998-7035)
- Jianying Pei (ORCID: https://orcid.org/0000-0003-0108-9230)
- Lifeng Yan (ORCID: https://orcid.org/0000-0002-6063-270X)
- Wendi Wang (ORCID: https://orcid.org/0000-0003-4741-7789)
- Yawei Zhou
Institutions
- Minzu University of China (CN)
- Gansu Provincial Maternal and Child Health Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12884-024-06950-w
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Gansu Province