Risk Factors for Unplanned Emergency Department Visits in Patients with Nasopharyngeal Carcinoma During Radiotherapy

<b>Background/Objectives:</b> Nasopharyngeal carcinoma (NPC) is commonly treated with radiotherapy (RT) or concurrent chemoradiotherapy (CCRT). However, unplanned emergency department (ED) visits during treatment can disrupt therapy and impact patient outcomes. This study aims to identify the risk factors associated with unplanned ED visits in patients with NPC receiving RT or CCRT. <b>Methods:</b> We retrospectively analyzed 2111 patients with NPC treated between 2001 and 2019 at Chang Gung Memorial Hospital. Patients were categorized based on whether they experienced an unplanned ED visit during or up to three months post-treatment. Demographic and clinical variables were compared using the Chi-squared test, and survival outcomes were assessed using Kaplan-Meier analysis. <b>Results:</b> Among the cohort, 573 patients (27.2%) experienced at least 1 unplanned ED visit. Risk factors for unplanned ED visits included older age (<i>p</i> < 0.001), hypertension (<i>p</i> < 0.001), higher Charlson Comorbidity Index (<i>p</i> = 0.001), and advanced clinical stage (T stage, <i>p</i> = 0.0046; N stage, <i>p</i> = 0.0034; M stage, <i>p</i> = 0.0008). No significant difference in ED visit rates was observed between RT alone and CCRT groups. <b>Conclusions:</b> Unplanned ED visits were common during NPC treatment, with risk factors primarily related to patient age, comorbidities, and disease stage. Identifying high-risk patients may enable interventions to reduce ED visits, improve survival outcomes, and alleviate healthcare costs.