Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) – A single-cell RNA sequencing analysis
Our study unveils the intricate interplay of ICMs in OPSCC, emphasizing the necessity for personalized therapeutic approaches based on HPV status and immune profiles. The identified ICMs, including PD1, CD27, and CTLA4, are promising candidates for further investigation and may enhance immunotherapeutic interventions in the HPV-dependent treatment strategies for OPSCC.
Authors
- Emma V. King (ORCID: https://orcid.org/0000-0003-0658-1873)
- Hans Armin Kestler (ORCID: https://orcid.org/0000-0002-4759-5254)
- Johann Michael Kraus (ORCID: https://orcid.org/0000-0002-9534-6295)
- Johannes Doescher (ORCID: https://orcid.org/0000-0001-8997-8387)
- Julius Vahl (ORCID: https://orcid.org/0000-0002-4481-7085)
- Patrick J. Schuler (ORCID: https://orcid.org/0000-0002-1065-8709)
- Jasmin Ezić (ORCID: https://orcid.org/0009-0003-6592-3287)
- Ayla Grages
- Cornelia Brunner (ORCID: https://orcid.org/0000-0002-6456-5508)
- Adrian von Witzleben (ORCID: https://orcid.org/0000-0001-6766-4758)
- Simon Laban (ORCID: https://orcid.org/0000-0001-6732-7137)
- Christian H. Ottensmeier (ORCID: https://orcid.org/0000-0003-3619-1657)
- Jaya Thomas (ORCID: https://orcid.org/0000-0002-3569-9101)
- Thomas K. Hoffmann (ORCID: https://orcid.org/0000-0001-5127-3779)
Institutions
- Institute of Cancer Research (GB)
- University of Augsburg (DE)
- Universität Ulm (DE)
- Poole Hospital (GB)
- University Hospital Ulm (DE)
- University of Southampton (GB)
Publication Details
- Journal
- Oral Oncology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1016/j.oraloncology.2024.107107
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Deutsche Forschungsgemeinschaft
- Universität Ulm