Shared genetic architecture of non‐viral cirrhosis with several pleiotropic traits: A nested case‐control study in the <scp>UK</scp> Biobank
This study provides a comprehensive assessment of the shared genetic architecture of non-viral cirrhosis predisposition and numerous polygenic and pleiotropic traits, most notably BMI, alanine aminotransferase, and diabetes. These findings provide new information on underlying comorbid conditions that can increase the non-viral cirrhosis risk.
Authors
- Jinyoung Byun (ORCID: https://orcid.org/0000-0001-8579-1435)
- Younghun Han (ORCID: https://orcid.org/0000-0001-5048-8479)
- Hashem B. El‐Serag (ORCID: https://orcid.org/0000-0001-5964-7579)
- Christopher Ian Amos (ORCID: https://orcid.org/0000-0002-8540-7023)
- Hyeyeun Lim (ORCID: https://orcid.org/0000-0001-5568-7549)
- Aaron P. Thrift (ORCID: https://orcid.org/0000-0002-0084-5308)
- Xiangjun Xiao (ORCID: https://orcid.org/0009-0006-5827-7661)
- Goo Jia Jun (ORCID: https://orcid.org/0000-0003-0891-0204)
- Stacia M. DeSantis (ORCID: https://orcid.org/0000-0002-3400-1031)
- Hyun‐seok Kim (ORCID: https://orcid.org/0000-0002-0376-0836)
- Fasiha Kanwal (ORCID: https://orcid.org/0000-0001-6715-3966)
- Shaobin Lin (ORCID: https://orcid.org/0000-0001-6272-3421)
Institutions
- Cedars-Sinai Medical Center (US)
- Michael E. DeBakey VA Medical Center (US)
- Baylor College of Medicine (US)
- Colgate University (US)
- Houston Institute for Clinical Research (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Liver international communications.
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1002/lci2.70002
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health
- National Human Genome Research Institute
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- Division of Cancer Epidemiology and Genetics, National Cancer Institute