Abstract 4145373: PREVALENCE OF NON-RHEUMATIC MITRAL STENOSIS IN CHRONIC KIDNEY DISEASE: NATIONAL IN-PATIENT SAMPLE ANALYSIS

Background: There have been several studies postulating the association between Mitral valve stenosis (MS) and Chronic Kidney Disease (CKD). Accelerated calcification of the mitral valve is the postulated pathophysioloigcal mechanism. AIM/ RESEARCH QUESTION Aim of the study is to analyze the prevalence of non-rheumatic mitral stenosis (MS) in patients with CKD and End Stage Renal Disease (ESRD) and to assess the association between the conditions. Methods: Using the National In-Patient Sample (NIS) 2019, admissions with documented CKD and ESRD were identified. The prevalence of non rheumatic Mitral stenosis (MS) in the admission cohort was analyzed. Chi-square test was used to analyze the association between the two conditions. RESULTS: We identified 4329 admissions with overlapping diagnoses of non-rheumatic MS and CKD, and 905 admissions with overlapping diagnoses of non-rheumatic MS and ESRD. The prevalence of MS in admissions with the diagnosis of CKD was 43.33% (41.14 – 45.84). Prevalence of MS in admissions with ESRD was 56.07% (49.24 - 64.31). There was significant association between MS and CKD, noted with an Odds ratio of 4.14 (3.78 – 4.52, p=0.00) and also between diagnoses of MS and ESRD: Odds ratio of 3.18 ( 2.73 -3.70, p=0.00). (TABLE 1) Conclusions: Based on our analysis, nearly half of the admissions with documented CKD and ESRD did have diagnosis of Mitral stenosis. The association between the conditions was statistically significant.