Abstract 4145945: Comparison of Catheter Ablation of Ventricular Tachycardia Between Ischemic and Non-ischemic Cardiomyopathy

Background: Ventricular Tachycardia (VT) is a common arrhythmia encountered in ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM). VT ablation is one of the treatment options of VT in ICM and NICM. There is scarcity of research comparing the outcomes of VT ablation in ICM and NICM. Methods: This is an analysis of the National Inpatient Sample of the years 2016 to 2020. We identified patients who were admitted for VT ablation using ICD-10-PCS codes. We divided the population into two groups by secondary diagnosis of ICM and NICM. The risk of mortality and in-hospital complications in the VT ablation/ICM group was compared to the VT ablation/NICM group using multivariate logistic regression analysis. Results: During 2016-2020, there were a total of 246240 patients who were admitted with for VT ablation, of which 28745(11.7%) patients had ICM while 58989 (23.95%) had NICM. After adjusting for demographics, VT ablation with NICM had lower odds of cardiogenic shock (aOR (adjusted odds ratio) 0.80; 95% CI 0.67–0.95 p =0.012), invasive mechanical ventilation (aOR 0.65; 95% CI 0.53–0.78p < 0.001), lower length of stay (LOS) (aMD (adjusted mean difference) - 0.42; 95% CI -0.7 – -0.14 days p= 0.003) but higher odds of arrhythmia other than VT (aOR 1.33; 95% CI 1.2 – 1.49 p<0.001), compared to VT ablation with ICM. (Figure 1) Conclusion: VT ablation in NICM has lower odds of cardiogenic shock, invasive mechanical ventilation, and lower LOS but higher odds of arrhythmia other than VT, compared to VT ablation in ICM. Further studies are needed to elucidate it further.