Abstract 4147768: Demographic Variations in Ischemic heart disease-related Mortality of Breast Cancer

Methods: Data were collected using Surveillance, Epidemiology, and End Results, SEERS at 8.4.2 database using Incidence-Based Mortality. The analysis included 17 SEER Registries and data from 2000 to 2020. Selection criteria included malignant breast cancer cases with known ages. Age-adjusted rates were displaced as cases per 100,000, standardized to the 2000 US Standard Population and confidence intervals (95% using Tiwari modification), and standard errors were calculated. Results: Our study included a total of 25,027 breast cancer cases related to ischemic heart disease. The ischemic heart disease-related incidence-based mortality for breast cancer was 1.4 per 100,000 populations. When stratified by gender, the rate was significantly lower among males (0.1) compared to females (2.3). Ischemic heart disease related death also exhibited racial disparities, higher in Black individuals (1.7), compared to White (1.5), American Indian/Alaska Native individuals (0.7) and Asian or Pacific Islanders (0.7). Temporal trends, spanning from 2000 to 2019 in five-year intervals, revealed a consistent decline in ischemic heart disease-related mortality rates, with rates dropping from 0.7 in 2000-2004 to 0.1 in 2015-2019. Incidence-based mortality, ischemic heart disease-related mortality rates were influenced by household income, with rates decreasing as income levels rose. The rates were highest for those with incomes below $35,000 (1.7) and lowest for those earning above $75,000 (1.3). Discussion: The findings of our study shed light on the socioeconomic factors associated with ischemic heart disease-related mortality of breast cancer. The observed variations in incidence-based mortality rates among genders and racial groups emphasize the complex interplay of biological and sociodemographic factors. Temporal trends reveal declining mortality rates signify potential improvements in healthcare interventions and early detection. The association between higher household income and lower mortality rates suggests a socio-economic dimension in breast cancer outcomes. Notably, the lower ischemic heart disease-related mortality rates in breast cancer underscore the importance of understanding and addressing treatment-related cardiovascular risks. These insights underscore the need for integrated healthcare strategies that consider both breast cancer and cardiovascular health, aiming to provide comprehensive care for affected individuals.