Abstract 4147290: The association between alcohol intake and pericarditis and myocarditis: The "All of Us” Research Program

Introduction: Alcohol consumption is associated with an increase in pro-inflammatory cytokines. Acute non-infectious pericarditis may be a consequence of the alcohol-related inflammatory process. This study investigates the association between excessive alcohol consumption and the risk of acute pericarditis and myocarditis. Hypothesis: Alcohol use may be associated with myocarditis and pericarditis through oxidative stress, immunological dysfunction, and direct toxicity to the heart muscle. Methods: This is a cross-sectional study of participants in the All of Us study at the time of enrollment. Alcohol use, our primary exposure was measured using the Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) score. Participants were stratified based on their AUDIT scores into Low risk-(males with Audit less than 4, females with Audit less than 3),moderate risk (AUDIT 4-5 in males, 3-5 in females), high risk (AUDIT 6-7 in both males and females) severe risk (AUDIT 8-12 in both males and females). The diagnosis of pericarditis and myocarditis was identified using electronic health records at the time of enrollment. The study adjusted baseline age, sex, race, educational status, income, health insurance, and smoking status. Logistic regression models were used to evaluate the association between alcohol intake and myocarditis/pericarditis. Models were adjusted for age, sex, race, educational status, income, health insurance, and smoking status. Results: Out of 135,010 eligible participants at baseline, 220 cases of myocarditis and pericarditis were detected. People with severe alcohol intake were (n=4825) more likely to be male (n, 3125, 64.8%%), less likely to be insured (n, %=4320, 89.5%) and less likely current cigarette smokers (n, %= 1007, 9.3%). The odds of developing myocarditis or pericarditis were not statistically significantly different with increasing AUDIT-C categories as compared to never- after adjusting for confounders. (table 1) Conclusion: There was no significant association found between higher AUDIT scores and an elevated risk of myocarditis and pericarditis.