Abstract 4147751: Outcomes of Concomitant Longitudinal Sleeve Gastrectomy and Mechanical Circulatory Support in Patients with Morbid Obesity

Introduction/Background: Obesity and heart failure often co-exist as either a cause or effect of one another. Patients with morbid obesity have few options in terms of definitive therapies to treat heart failure. There is limited outcome data on patients with obesity and left ventricular assist devices (LVADs). Our institution has used a concomitant procedure that implants a gastric sleeve at the same time as an LVAD. Research Question/Hypothesis: We hypothesize that the concomitant procedure enables subjects to attain transplant eligibility while limiting complications. Goals/Aims: Analyze institutional data to identify baseline outcome statistics for the concomitant procedure. Methods/Approach: We retrospectively reviewed records from patients with morbid obesity (body mass index > 35 kg/m 2 ) who underwent concomitant longitudinal sleeve gastrectomy (LSG) and LVAD implantation between November 2013 and March 2022. A minimum of 2 years of follow-up data was collected. The primary endpoint was transplant listing or LVAD explantation. Secondary outcomes included mortality and related complication rates. Results/Data: A total of 56 patients were included for analysis. The concomitant LSG and LVAD procedure has enabled 82.1% (46/56) of patients to reduce their BMI to below 35 kg/m 2 . Overall, 60.7% (34/56) of subjects met the primary endpoint; the median number of days to listing or explantation was 401. Thirty-two patients were listed for transplant, and 17 have been successfully transplanted. Two patients demonstrated recovery and underwent successful explant of the LVAD and remained New York Heart Association Class II at follow-up. Six subjects died before receiving a transplant, with two being listed at the time of death (Figure). Complications were noted, but they do not seem to limit the ultimate goal of transplantation. Conclusions: A significant portion of patients who were ineligible for heart transplantation were able to reduce their BMI and become eligible. The incidence of complications for this concomitant procedure is low. Multicenter studies are needed to establish this approach as a standard of care for patients with morbid obesity and stage D heart failure.