Abstract 4148118: Causes of Thirty Day Readmission Following ICD Placement in Heart Failure Patient with Amyloidosis

Background and Objectives: Data regarding readmission rate following ICD placement in heart failure patients with Cardiac amyloidosis are scare. We attempted to study 30-day readmission rate following ICD placement in these patients and the common causes of readmission. Methods: We utilized the Nationwide Readmission Database from 2016 to 2020 and included patients more than 18 years of age who were admitted for placement of Implantable Cardiac Defibrillator (ICD) and had secondary diagnosis of heart failure and amyloidosis. We used International Classification of Disease, Tenth Revision, Clinical Modification (ICD10 CM) codes to identify patients. The primary outcome was the 30-day readmission rate, and secondary outcomes were mortality rates, and common reasons for readmission. Results: We identified a total of 457 patients who underwent placement of ICD and had heart failure with amyloidosis, among which mean age was 69 years and 25.42% were females. The 30-day readmission rate was 19.50%. Mortality rate was higher in readmitted patients (7.12%) as compared to index admission (3.82%). Most common causes of readmission were hypertension and heart failure with CKD stage 1 to 4(22%), hypertensive heart disease with heart failure (8.35%), hypertensive heart disease with CKD 5 or ESRD (7.58%), Acute Kidney Injury (5.94%), Non-specific chest pain (5.56%), Organ specific amyloidosis (5.43%), Cellulitis (3.68%), Acute on chronic systolic heart failure (3.56%), and Acute systolic heart failure (3.17%) Conclusion: The thirty-day readmission rate was 19.50% and most common cause of readmission was hypertension and heart failure with CKD. Improvement of management strategies is needed to address these causes and improve patient outcomes.