Acute tear versus chronic-degenerated rotator cuff pathologies are associated with divergent tendon metabolite profiles
Overall, this study demonstrates that distinct metabolite profiles are associated with injury types, and that therapeutic strategies should address both cellular and matrix components regardless of injury induction. The specific pathways identified paired with validated, established, treatment methods may serve as novel therapeutic targets for patients who suffer from rotator cuff injuries.
Authors
- Kelly S. Santangelo (ORCID: https://orcid.org/0000-0002-2348-594X)
- Kendra M. Andrie
- David D. Frisbie (ORCID: https://orcid.org/0000-0002-0900-891X)
- Katie J. Sikes (ORCID: https://orcid.org/0000-0002-3750-4777)
- Adam Blair Yanke (ORCID: https://orcid.org/0000-0002-9601-4217)
- Sara Wist
- Nikhil N. Verma (ORCID: https://orcid.org/0000-0001-9875-2769)
- Brian J. Cole (ORCID: https://orcid.org/0000-0002-4006-2113)
Institutions
- Rush University Medical Center (US)
- IDEXX Laboratories (United States) (US)
- Colorado State University (US)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1080/03008207.2024.2425867
- Citations
- 1
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Orthopaedic Research and Education Foundation