FOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma
We demonstrated that FOXA1 prevents tumor immune evasion by inhibiting IFN-γ induced PD-L1 expression in NPC cells. Our research findings provide new insights into the immunotherapeutic biomarkers and targets for NPC, which is important for the clinical application of programmed cell death protein-1/PD-L1 antibodies in NPC.
Authors
- Ying Liu (ORCID: https://orcid.org/0000-0001-5834-6934)
- Junshang Ge
- Pan Chen (ORCID: https://orcid.org/0000-0002-0182-2909)
- Bo Xiang (ORCID: https://orcid.org/0000-0003-2641-5434)
- Zhaoyang Zeng (ORCID: https://orcid.org/0000-0002-0648-0565)
- Guiyuan Li (ORCID: https://orcid.org/0000-0001-9705-5806)
- Wei Xiong (ORCID: https://orcid.org/0000-0002-3017-9895)
- Mei Yi
Institutions
- Central South University (CN)
- Ministry of Education (SA)
- Hunan Cancer Hospital (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/jitc-2024-010091
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- Central South University
- Natural Science Foundation of Hainan Province