RUNX2 is stabilised by TAZ and drives pulmonary artery calcification and lung vascular remodelling in pulmonary hypertension due to left heart disease
Pulmonary hypertension due to left heart disease is associated with pulmonary artery calcification that is driven by TAZ-dependent stabilisation of RUNX2, causing osteogenic reprogramming of pulmonary artery smooth muscle cells. The TAZ-RUNX2 axis may present a therapeutic target in pulmonary hypertension due to left heart disease.
Authors
- Tara Gransar
- Ioana Alesutan (ORCID: https://orcid.org/0000-0002-2145-3653)
- Juquan Yao
- Jana Grune (ORCID: https://orcid.org/0000-0001-6209-7416)
- Mariya M. Kucherenko (ORCID: https://orcid.org/0000-0002-8637-2037)
- Wolfgang M. Kuebler (ORCID: https://orcid.org/0000-0003-4100-2961)
- Szandor Simmons (ORCID: https://orcid.org/0000-0002-5309-9863)
- N. Nambiar Veetil
- Jakob Voelkl (ORCID: https://orcid.org/0000-0002-6318-5087)
- Christoph Knosalla (ORCID: https://orcid.org/0000-0002-8127-5019)
- Gabriela Salinas (ORCID: https://orcid.org/0000-0001-8269-2669)
- Shao‐Fei Liu (ORCID: https://orcid.org/0000-0001-6178-5938)
- Qiuhua Li (ORCID: https://orcid.org/0000-0002-2797-4417)
- Pengchao Sang
Institutions
- Johannes Kepler University of Linz (AT)
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Humboldt-Universität zu Berlin (DE)
- Deutsches Herzzentrum der Charité (DE)
- Laser Systems & Solutions of Europe (France) (FR)
- Universitätsmedizin Göttingen (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1183/13993003.00844-2023
- Citations
- 15
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 4.89
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Austrian Science Fund
- China Scholarship Council