Why Symptoms Linger in Quiescent Crohn’s Disease: Investigating the Impact of Sulfidogenic Microbes and Sulfur Metabolic Pathways
Microbial-derived sulfur pathways and downstream mitochondrial function are perturbed in qCD + S, which implicate H2S signaling in the pathogenesis of this condition. Future studies will determine whether targeting H2S pathways results in improved quality of life in qCD + S.
Authors
- Nobuhiko Kamada (ORCID: https://orcid.org/0000-0002-1980-4178)
- Krishna Rao (ORCID: https://orcid.org/0000-0002-9213-7850)
- Shrinivas Bishu (ORCID: https://orcid.org/0000-0003-4823-5805)
- Vincent B. Young (ORCID: https://orcid.org/0000-0003-3687-2364)
- Allen Lee (ORCID: https://orcid.org/0000-0002-4861-7646)
- Jonathan L. Golob (ORCID: https://orcid.org/0000-0003-0009-5815)
- Peter Higgins (ORCID: https://orcid.org/0000-0003-1366-4028)
- Jeffrey Berinstein (ORCID: https://orcid.org/0000-0001-7631-9665)
- Chung Owyang (ORCID: https://orcid.org/0000-0002-1746-2370)
- Prashant Singh (ORCID: https://orcid.org/0000-0002-5677-836X)
- William D Chey
Institutions
- University of Michigan (US)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1093/ibd/izae238
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Crohn's and Colitis Foundation
- National Institutes of Health