Combined therapy of a case of multiple venous malformation with FLT4 gene mutation

As the study of vascular anomalies progresses, it is imperative for plastic surgeons to individualize their in-depth research and practice to develop more effective and personalized treatment plans. Recent advancements in genome sequencing technology have highlighted the importance of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in the formation and alteration of vascularity. However, definitive reports regarding mutations associated with this locus and treatment experiences remain scarce. Herein, we report a clinical case of multiple venous malformations with mutations in VEGFR3 ( FLT4 ). We implemented a comprehensive approach, including local lesion excision of the left foot and trunk, oral propranolol administration, and local physiotherapy. After two years of follow-up, the patient’s left foot venous malformation did not recur, and he expressed satisfaction with the outcomes of the combined therapy. This case offers valuable insights into the clinical management of this mutant type and similar presentations of multiple venous malformations.