NINJ1: Bridging lytic cell death and inflammation therapy
NINJ1, a critical transmembrane protein in inflammation, governs diverse biological processes. Recent breakthroughs revealed NINJ1's structural basis for plasma membrane rupture, which is directly linked to lytic cell death. This discussion explores NINJ1's functions, focusing on its pivotal role in lytic cell death regulation and the latest advancements in targeted therapeutic interventions.
Authors
- Shiwei Duan (ORCID: https://orcid.org/0000-0001-7682-2877)
- Jinze Shen (ORCID: https://orcid.org/0000-0001-8822-2561)
- Ruixiu Chen
Institutions
- Communication University of Zhejiang (CN)
- Hangzhou City University
Publication Details
- Journal
- Cell Death and Disease
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1038/s41419-024-07203-6
- Citations
- 11
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.65