Succinate exacerbates mastitis in mice via extracellular vesicles derived from the gut microbiota: a potential new mechanism for mastitis
Our findings suggest that succinate promotes mastitis through the proliferation of enteric pathogens and mEVs production, suggesting a potential strategy for mastitis intervention on the basis of intestinal metabolic regulation and pathogen inhibition. The role of mEVs in interspecific communication has also been elucidated.
Authors
- Caijun Zhao (ORCID: https://orcid.org/0000-0002-6435-8437)
- Xiaoyu Hu (ORCID: https://orcid.org/0000-0002-0339-5357)
- Chen‐Yu Zou (ORCID: https://orcid.org/0000-0003-2950-2779)
- Yiheng Liu (ORCID: https://orcid.org/0000-0002-7778-2368)
- Xiaotong Zhao (ORCID: https://orcid.org/0000-0002-0463-2510)
- Yunhe Fu (ORCID: https://orcid.org/0000-0002-3258-2610)
- Naisheng Zhang
- Ruibo Tang
- Cong Ye
- Jiaxin Xie (ORCID: https://orcid.org/0000-0002-6352-1589)
- Yubo Hu (ORCID: https://orcid.org/0000-0003-2049-3829)
- Min Qiu
- Jun Wang (ORCID: https://orcid.org/0000-0002-7437-8503)
Institutions
- Jilin University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12951-024-02997-1
- Citations
- 15
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Postdoctoral Program for Innovative Talents