The acyltransferase transmembrane protein 68 regulates breast cancer cell proliferation by modulating triacylglycerol metabolism
TMEM68 is highly expressed in breast cancer and negatively correlated with survival. Its overexpression promotes breast cancer cell proliferation while knockdown has varied effects depending on TMEM68 levels. TMEM68 regulates intracellular TAG and LDs contents along with alterations in glycerophospholipids. These findings suggest that TMEM68 may drive breast cancer cells proliferation by modulating TAG and LD content.
Authors
- Fansi Zeng
- Quan Sun (ORCID: https://orcid.org/0000-0002-7228-9363)
- Zheng Zhao (ORCID: https://orcid.org/0000-0002-3067-8088)
- Pingan Chang (ORCID: https://orcid.org/0000-0002-2244-1929)
- Qing Yu (ORCID: https://orcid.org/0009-0001-1650-9130)
- Huimin Pang
- Xiaohong He (ORCID: https://orcid.org/0000-0001-6032-9316)
Institutions
- Chongqing University of Posts and Telecommunications (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1186/s12944-024-02369-6
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Chongqing Science and Technology Commission
- Chongqing Municipal Education Commission
- Centre Scientifique et Technique du Bâtiment