B2M or CIITA knockdown decreased the alloimmune response of dental pulp stem cells: an in vitro study
Genetic knockdown of B2M or CIITA in DPSCs substantially reduced their immunogenicity without compromising their stemness, thereby broadening the clinical application of DPSCs in cell therapy and tissue regeneration.
Authors
- Junqing Liu (ORCID: https://orcid.org/0000-0001-5129-1678)
- Jialin Zhong
- Rong Cen
- Xiaofei Zhu (ORCID: https://orcid.org/0000-0002-4700-3431)
- Chengfei Zhang (ORCID: https://orcid.org/0000-0002-6016-9436)
- Jun Kang (ORCID: https://orcid.org/0000-0001-6692-1230)
- Yuchen Zhang (ORCID: https://orcid.org/0000-0003-3572-9830)
- Shulan Lin
- Yihan Chen (ORCID: https://orcid.org/0000-0002-1666-8561)
- Mingxin Hu (ORCID: https://orcid.org/0000-0001-6757-9780)
- Ye Liang
Institutions
- Boston University (US)
- Third Affiliated Hospital of Zhengzhou University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s13287-024-04023-5
- Citations
- 4
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- University Grants Committee