Sclerosing mucoepidermoid carcinoma of salivary glands
Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma with scanty cellular atypia characterized by marked fibrosis/sclerosis and a rich inflammatory infiltrate. Herein, we report 25 unpublished cases of SMEC, two of them with prominent eosinophilia (2/25; 8%) and three with abundant IgG4-positive plasma cells (3/25; 12%). In our series of salivary SMEC, molecular analysis using fluorescence in situ hybridization (FISH) and/or next-generation sequencing (NGS) provided evidence of MAML2 gene rearrangement in 18 cases of the 21 analyzable cases tested (86%), while this gene locus was intact in 3 cases (14%). This study focuses on the diagnostic criteria of salivary SMEC given its challenge of abundant collagenous stroma, minimal residual neoplastic areas, and inconspicuous mucous cells. Follow-up data of our cases indicate that salivary SMECs have favorable outcomes. Molecular analysis for MAML2 gene rearrangement suggests that SMECs of salivary glands represent a rare variant of conventional low-grade MECs of salivary glands. In contrast, SMECs of the thyroid gland are genetically distinct from salivary-type thyroid MECs.
Authors
- Stephan Ihrler (ORCID: https://orcid.org/0000-0002-6183-0249)
- Ilmo Leivo (ORCID: https://orcid.org/0000-0002-9609-1597)
- Ján Laco (ORCID: https://orcid.org/0000-0002-9602-7501)
- Abbas Agaimy (ORCID: https://orcid.org/0000-0002-0445-8161)
- Alena Skálová (ORCID: https://orcid.org/0000-0001-5070-0310)
- Gisele de Rezende
- Miguel Rito (ORCID: https://orcid.org/0000-0002-0226-5905)
- Petr Šteiner
- Martina Bradová (ORCID: https://orcid.org/0000-0002-5829-5572)
- Senada Koljenović (ORCID: https://orcid.org/0000-0002-5185-3455)
- Isabel Fonseca (ORCID: https://orcid.org/0000-0002-1359-6494)
- Veronika Hájková (ORCID: https://orcid.org/0009-0001-5514-2327)
- Bacem K. Othman (ORCID: https://orcid.org/0000-0002-4897-9727)
- Roderick H. W. Simpson
- Petr Grossmann
- Michal Michal
- Montse Gomà (ORCID: https://orcid.org/0000-0003-0258-1526)
Institutions
- University of Lisbon (PT)
- University of Antwerp (BE)
- University of Turku (FI)
- University of Calgary (CA)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Charles University (CZ)
- Erasmus MC (NL)
- Turku University Hospital (FI)
- Bellvitge University Hospital (ES)
- Universitätsklinikum Erlangen (DE)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Antwerp University Hospital (BE)
- Biopticka Laborator (Czechia) (CZ)
- University Hospital Hradec Králové (CZ)
- Comprehensive Cancer Center Erlangen (DE)
Publication Details
- Journal
- Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1007/s00428-024-03970-x
- Citations
- 5
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Univerzita Karlova v Praze
- European Commission
- Turun Yliopistollinen Keskussairaala