Osteopenic Effect of Disulfiram Therapy in Patients With Alcohol Use Disorder

This study highlights a significant reduction in lumbar-spine bone mineral density and an increase in the β-CTx/osteocalcin ratio in patients with alcohol use disorder undergoing disulfiram therapy. These findings suggest that, despite the benefits of alcohol cessation facilitated by disulfiram, there is a notable risk of osteopenia that warrants careful monitoring. Clinicians should consider regular bone health assessments and proactive measures to mitigate bone density loss in this patient population.