Abstract 4140296: Trajectory of Diastolic Dysfunction in Patients with Takotsubo Syndrome

Introduction: Takotsubo Syndrome (TS) is associated with impairments in systolic function, but less information is available on diastolic function. Elucidating changes in diastolic function during the months following a TS episode is important to understand the long-term prognosis of this condition. Aim: To evaluate changes in diastolic function of patients with TS at follow-up (FU) vs. admission. Hypothesis: Echocardiographic measures of diastolic dysfunction will show improvements at follow-up compared to admission. Methods: Prospectively enrolled participants with a confirmed diagnosis of TS received a transthoracic echocardiogram at hospital admission (TTE1) and during FU (TTE2). TTE1 was performed for clinical reasons and data was abstracted from medical records. TTE2 was performed as part of an ongoing prospective study and analyzed by a cardiologist. To assess diastolic dysfunction, the following measures were considered: left atrial volume index (LAVI), e’ septal (e’s), e’ lateral (e’l), peak tricuspid velocity (TRV max), E/A, and mean E/e’. Left ventricular ejection fraction (LVEF) was also included. Differences were analyzed using paired samples t-test. P-values <0.05 were considered significant. Sociodemographic information was collected through self-report surveys. Medical and psychiatric history were abstracted from medical records. Results: Patients (n=49; age=64.6 ± 9.3 years) were 98% female and 94% White. At FU (average = 2.2 months), systolic function had returned to normal (p <.001). At admission, diastolic function measures were within normal range with the exception of e’s and e’l. At FU, patients showed improvements in e’l (p = < .001) and TRV max (p= 0.039). There were no changes in LAVI, E/A, and mean E/e’. Conclusion: In this longitudinal sample of TS patients, minimal alterations of diastolic function were detected at admission, which improved at FU. The clinical significance of these findings need further study in larger, more diverse samples.