Abstract 4140405: Hospital outcomes of patients with type 1 diabetes mellitus and moderate and severe congenital heart disease

Background: Advancements in life-saving treatment for patients with moderate and severe congenital heart disease (CHD) has led to the exponential growth of a novel population of individuals with CHD who previously did not survive beyond infancy. Little is known about the impact of other medical comorbidities on the overall health of these individuals. We sought to assess the effect of comorbid Type 1 diabetes (T1DM) on hospitalized individuals with CHD. Hypothesis: We hypothesized that individuals with CHD who had comorbid T1DM would have worse hospital outcomes than those without diabetes of any type. Methods: We conducted a retrospective review of the Vizient® Clinical Data Base (national, administrative database) for admissions from 10/2019-12/2023 with ICD-10 codes for moderate and severe CHD, aged 1 to 50 years. Data included: demographics, hospital outcomes and costs. Comparisons were made between those with ICD-10 codes for T1DM (E10 – E10.9) and those without any diabetes ICD-10 codes (E10 – E10.9, E11 – E11.9) using t-tests for normally distributed data, Mann-Whitney U test for non-normally distributed data and χ 2 for categorical data. Results: There were 64,189 CHD admissions, 846 (13.2%) with T1DM. Details are shown in Table 1. The T1DM group were younger, had a higher prevalence of Whites (consistent with known T1DM epidemiology), higher in-hospital mortality and lower hospital costs. Conclusions: This review of a national administrative database has found that hospitalized individuals with CHD and comorbid T1DM are hospitalized at younger ages and are at increased risk for in-hospital mortality. Despite this, hospital costs are lower. This suggests an additional negative effect of T1DM compared to CHD alone. Further studies are needed to examine potential interventions to reduce mortality in this population.