Abstract 4140625: Does the Cord predict the Course? Trend And Outcome of Myocardial Infarction in Patients With Spinal Cord Injury; a Retrospective Population-Based Analysis

Introduction: Spinal cord injury (SCI) has been shown to increase the risk of cardiovascular diseases such as myocardial infarction (MI), atrial fibrillation, and heart failure. Impaired mobility and dysautonomia have been suggested to play a role. We evaluated MI outcomes in patients with SCI. Methods: This retrospective cohort study used the National Inpatient Sample (2016-2020) database. We identified hospitalizations with a diagnosis of MI using their ICD-10 codes and then stratified them based on the presence or absence of SCI. Our outcome of interest was in-hospital mortality. A multivariate logistic regression model was used to account for confounders and estimate the probability of the outcome. Results: The number of patients hospitalized with MI and a history of SCI was 560, while 3,190,369 patients had MI with no history of SCI. The mean age of the SCI population was 66.9 years, compared to 62 years in the group without SCI. The SCI group were predominantly male 85%, 72% White, 14% Black, and 7% Hispanic. The SCI population had a higher association with in-patient mortality (adjusted odds ratio: 2.5, p= 0.013, CI 1.21 - 5.03) than the group without SCI. Conclusions: Our analysis showed that among the population admitted for MI, those with SCI had a higher association with in-hospital mortality than those without SCI. Also, SCI patients admitted for MI tend to be of male sex. More research is needed to explore our findings further.